The results revealed that PNA-binding GC B cells clearly developed in the spleen of Gpr97-KO mice, which indicated an intact GC formation despite Gpr97 deletion.
Lymphomas are hematological abnormalities of the B or T lymphocytes that may develop in the lymph nodes, spleen, bone marrow and blood.
Granulomatous disease, often with central necrosis, developed in the lungs, spleen, and lymph nodes of infected animals.
We have shown here that reconstituted NOD/Scid mice, regardless of age, are devoid of human CD56+ cells while reconstituted newborn Rag2−/−/γc−/− mice develop them in the spleen, lymph nodes and thymus.
R172H mutp53 knock-in (Trp53 R172H/R172H ) mice mainly develop lymphomas in the spleen and thymus (Lang et al., 2004; Olive et al., 2004).
A study using goats to compare subcutaneous versus intraperitoneal inoculation showed that, in animals inoculated intraperitoneally, septicemia with multiple microabscesses developed throughout the body, whereas in animals inoculated subcutaneously, localized abscesses developed in the lungs and spleen (22 ).
The vast majority (over 90%%) of cases are "pathologic" ASRs, which develop in a diseased spleen from the ample but specific range of disorders listed in Table 1.
Arthritis developed in the recipients of whole spleen cells regardless of whether the recipients received FTY720 or not.
In the absence of drug treatment, transplantation of 27 9.5.3 cells (3 × 10 cells/mouse) caused rapid B lymphoma development in NOD SCID mice, which killed the mice at 23 ± 3 (Mean ± SD) days post-transplantation. Necropsy revealed that B lymphomas were not only developed in the peritoneal cavity and spleen, but also often metastasized to the kidney, liver and lung.
Furthermore, dendritic cells develop in spleen by postnatal day 4 (Hinton et al., 2011).
In developed countries, the spleen is often palpable in early life due to extramedullary haematopoiesis, congestion and sequestration (Scott & Ferguson, 1966; Powars, 1975).
