The lung adenomas were developed in a mouse model expressing conditionally K- rasV12in the lung [ 5], one of the first in vivo settings used to demonstrate the role of senescence as an anti-tumor barrier in premalignant lesions [ 5].
The lesions develop in a predictable time, thus, this mouse is a good model to study alterations in tumorigenesis and progression [ 8].
In a tumor that has developed in a C57BL/6 mouse, 10 days after the subcutaneous injection of B16-F10 cells, nearly identical fragments were detected as in B16-F10 cells growing in a tissue culture (Fig. 3).
Finally, the PRL-responsive T37i cell line [18], derived from a BAT hibernoma developed in a transgenic mouse [20], was used to assess the molecular mechanisms by which PRLR signaling controls BAT differentiation.
The TIII cell-line was derived from the neck cutaneous nodule that developed in a RET mouse.
As an example, a CD4-rich T-cell lymphomas was found to have developed in a R26-Ptenfx/fx mouse at six weeks post-treatment (Figure 4C).
Notably, when translated to a mammalian system, PK 11195 treatment prevents the hepatic steatosis and glucose intolerance that develop in obese mice fed a HFD (Gut et al., 2013).
Several classes of breast tumors that develop in mouse models cluster into a basaloid sub-class, including tumors that develop in response to the proto-oncogene, Wnt1 [8].
Yet, adipocytes isolated from Nscl-2 mutant mice are insulin-resistant indicating that the metabolic changes that develop in mutant mice led to a relatively stable phenotype of adipocytes, which maintain these features in vitro for some time.
Although Tfh cells could develop in these mice, there was a reduction in the GC compartment size the percentage of plasma cells and, importantly, the amount of antigen-specific antibodies following immunization.
