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Endometrioid endometrial carcinoma (EEC), or Type 1 cancers, are oestrogen dependent, often develop in a background of atypical complex hyperplasia and account for over 75% of cases.
Most often, HCCs appear hypodense or isodense (Fig. 1) to the liver on unenhanced images but may appear hyperdense when they develop in a background of fatty liver.
Most hepatocellular carcinomas (HCC) develop in a background of underlying liver disease including chronic hepatitis B. However, the effect of antiviral therapy on the long-term outcome of patients with hepatitis B virus (HBV -related HBV -relatedwitHCChemoembolizatreated unclear.
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Our laboratory has performed preliminary analysis (data not shown) on three HPV-independent VSCC, categorised thus because tumours developed in a background of lichen sclerosus and/or differentiated VIN and tested negative for hrHPV DNA.
Nevertheless, the lack of any recurrent gross alteration in the genome of dNFs favors the idea that, genetically, NF1 inactivation in neurofibroma-initiating cells (precursor cells that have the capacity to differentiate into Schwann cells) might be sufficient for dermal neurofibromas to develop (in an NF1 background).
The mouse Brca1 Δ/Δ ;p53 Δ/Δ tumors also showed the gain on chromosome 2 but the p53 Δ/Δ tumors, on the other hand, did not show this gain at all, suggesting that this gain may selectively develop in a homologous repair deficient (HRD) background.
Thyroid carcinomas can develop in the background of a variety of follicular thyroid lesions in CNC patients despite biochemical euthyroid status and no palpable mass.
Opa1 tg mice were initially developed in a mixed genetic background of C57BL/6 × Sv129Ola and were backcrossed to C57BL/6 and Sv129 for more than ten generations.
The Tp53 C273X/C273X rat, which was developed in a Wistar Han background (referred to subsequently as the TP53-deficient Wistar rat), expressed primarily sarcomas and survived until about 4 months of age, whereas the Tp53 C273X/+ rats predominantly developed osteosarcoma, with onset of tumor occurring at around 43 weeks.
Steve Kandell of New York magazine wrote: "This is obviously the moment when Ben's begrudging respect for her becomes something else", and The Atlantic writer Scott Meslow wrote: "Parks and Recreation has allowed Ben to develop in the background so far, but his affection for Pawnee is clearly growing".
Hepatitis C virus-HCC is more likely to develop in the background of cirrhosis than HBV-HCC [ 12].
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