As the availability of ICI continues to develop, HPs should be involved in its regulation and peer review.
Thus, lack of GDF15 impairs proliferation and migration in the developing HP.
In the developing HP, cells migrating from the CA1 towards the DG include tangentially migrating interneurons.
Our data indicate that deletion of Gdf15 leads to an impairment of both proliferation and migration in the developing HP.
This is consistent with our findings in the developing HP, highlighting a defect in migration within the mutant CA1 region.
This is consistent with the dynamics of interneuron migration in the developing HP (Tricoire et al., 2011).
We have found that GDF15 affects EGFR signalling and expression in the developing HP, and that lack of GDF15 leads to altered proliferation and migration in this region.
We have shown that EGFR cells in the developing CA1 display morphological characteristics of tangentially migrating cells (Carrillo-García et al., 2010), indicating that EGFR signalling may contribute to migration also in the developing HP.
Moreover, our collaboration in iGEM has shown that the constraints of expertise and resources represent a significant barrier to developing HP work that tries to go beyond instrumental concerns.
In an attempt to externally validate the MWF-HP Score, it was also applied to 50 previously published US case reports of workers developing HP due to MWF exposure [Bernstein et al., 1995; Trout et al., 1996; Kreiss and Cox-Ganser, 1997; Zacharisen et al., 1998; Fox et al., 1999; Hodgson et al., 2001; Dangman et al., 2002; Weiss et al., 2002; Trout et al., 2003; Gupta and Rosenman, 2006].
