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Patients that did not develop dysfunction followed a similar pattern.
First, it was assumed for the composite primary outcome that patients who only had an initial laboratory value level sent for any given organ system did not go on to develop dysfunction of that organ.
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We observed that when young adult females are treated with doxorubicin (DXR), a widely used chemotherapeutic agent [19], the animals develop dysfunctions in multiple organs, including the brain, uterus, and ovaries.
The previously developed Dysfunction After Upper Gastrointestinal Surgery (DAUGS 32 scoring system has been further refined to include just 20 items.
The need for an increased amount of handling to keep the R6/2 mice active as the experiment progressed may be due to a developing dysfunction in their circadian rhythms.
Interestingly, while few develop haematological or hepatic failure, 48.9% and 40.0%, respectively, developed dysfunction of these systems.
The study instrument included locally developed dysfunction scales for men and women using a process described in [ 33].
35 In our study, approximately 14% developed dysfunction within a month that increased to 25% at 1 year after completion of therapy.
In addition, as reported below, βLKB1KO mice developed dysfunction of both hind limbs at approximately 7 and eight 8 for females and males, respectively.
To date no barrier function has been ascribed to the enhanced myofibroblast growth surrounding the capillaries in heart, lung, liver or kidney; although this may well be an important factor in the developing dysfunction of these organs.
Among the remaining 20 patients who did not present diaphragm dysfunction on admission, 11 (26 %) subsequently developed diaphragm dysfunction ("Acquired Dysfunction" pattern) and 9 (21 %) did not present any diaphragm dysfunction during the ICU stay ("No Dysfunction" pattern).
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