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5 Such patients may develop difficult-to-treat disease, characterised by frequent flares and persistent inflammation between flares which contribute to joint damage 6 and have a major impact on health-related quality of life 7 8 and an individual's ability to work.
Rather, the more likely clinical scenario is a patient who develops difficult-to-explain 'altered mental status', which may be either a depression in the level of consciousness or confusion or disorientation.
Gray says the cash boost from McCarthy's sale shows the way Scottish clubs must develop in difficult financial times.
This makes decisions on which services to develop very difficult.
As a consequence, the exact time at which CIN3+ lesions had developed was difficult to assess.
The parasite that causes the disease is transmitted to humans by bites from infected mosquitoes, and the complicated lifecycle of the parasite makes developing vaccines difficult.
"In what form the cooperation will develop, it's difficult to anticipate," Mr. Jassal said.
It's difficult to develop our game.
Does that make it difficult to develop a winning environment?
It is becoming increasingly difficult to develop new drugs active against resistant strains.
In contrast, virtues are habits, difficult to develop and therefore not accessible to all.
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CEO of Professional Science Editing for Scientists @ prosciediting.com