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Approximately 30 40% of all patients with diabetes develop diabetic nephropathy (1), and this is the leading cause of end-stage renal disease in the Western world.
It has been estimated that approximately one-third of the patients with type 1 diabetes develop diabetic nephropathy during their lifetime.
A substantial proportion of patients with type 1 diabetes will develop diabetic nephropathy years after onset of diabetes, although studies from selected centers suggest a declining incidence (6, 7).
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease and about 20% to 40% of patients with diabetes ultimately develop diabetic nephropathy[1], [2].
These observations suggest a genetic predisposition in individuals with type 1 diabetes who develop diabetic nephropathy, but as yet no gene has been identified.
For example, a person with chronic arthritis may develop mobility impairment; or a person with diabetes mellitus may develop diabetic retinopathy which impairs vision.
Similar(29)
A 48-year-old man with an 18-year history of poorly controlled diabetes developed diabetic nephropathy and received a kidney transplant.
During the study, 12 922 (26.0%) participants with type 2 diabetes mellitus developed diabetic retinopathy, of whom the vast majority (12 574 (97.3%)) developed background retinopathy.
CONCLUSIONS This is the first report of a patient with neonatal diabetes who developed diabetic nephropathy that progressed to end-stage renal disease.
Patients with type 1 diabetes are at risk of developing diabetic ketoacidosis (DKA).
Also, older patients with diabetes are at risk of developing diabetic retinopathy [ 15].
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