Exact(1)
Previous research has estimated that about one in six users who have used cocaine at least once will develop cocaine dependence [ 8].
Similar(59)
Deficits in executive function and response regulation as well as anxious-impulsive personality traits may represent endophenotypes associated with the risk of developing cocaine or amphetamine dependence.
In a recent PET study on adolescent boys with ADHD, we used a newly developed cocaine analogue radioligand, [C]PE2I, that binds selectively to the dopamine transporter [ 25, 49].
SD rats developed cocaine-induced CPP to each of the four doses of cocaine tested.
He would subsequently develop a cocaine habit and spend time in jail.
Within a year or two, he would develop a cocaine habit that would send his career off the rails, but there was no sign of that either.
He used the money to develop a cocaine habit, and when that money ran out, he shot a man during an armed robbery.
This procedure therefore captured the notion of vulnerability to develop compulsive cocaine taking behaviour.
Trait-like impulsive rats further show enhanced conditioned place preference to amphetamine (Yates et al., 2012), have a higher propensity to develop compulsive cocaine self-administration (Belin et al., 2008) and show increased rates of 3,4-methylenedioxymethamphetamine (MDMA -primed drug-seeking (Bird and Schenk, 2012) and cueinduced relapse for cocaine-seeking (EconoMDMA -primed, 2009).
When given an extended period of access to cocaine, HI but not HR rats developed compulsive cocaine seeking that persisted despite punishment (Belin et al., 2008) and showed a greater propensity to relapse after abstinence (Economidou et al., 2009).
Preston also developed a cocaine addiction.
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