Sentence examples for develop clefts from inspiring English sources

The tidemark represents the transition between calcified and uncalcified cartilage, an area known to advance, duplicate and develop clefts during the development of OA.

To support this hypothesis it was demonstrated that TGFβ3 null mice develop cleft palate [24].

Mice with ablation of Epithelial splicing regulatory protein (Esrp1) develop cleft lip and palate.

These mice also develop cleft palate as a result of micrognathia and failed palate shelf elevation due to physical obstruction by the tongue.

The importance of TGF β signaling in palatogenesis has been robustly demonstrated through animal models that lack TGF- β3 production (KO mice), which consistently develop cleft palate among other developmental abnormalities [ 41, 42].

These mice develop cleft palate as a result of abnormal TGF β activation via TGF- β receptor types I and III- (T βRI/T βRIII-) mediated TRAF6/TAK1/p38 signaling pathway.

The molecular composition of this cap reflected that of the fibrous connective tissue on the flank of the end bud and in developing clefts before bifurcation, suggesting that TGF-β1 might be the normal inducer [ 16].

African Americans exhibit the lowest likelihood of developing cleft lip and palate.

Importantly, the fact that Ahr /– mice developed cleft palates upon atRA excess allows us to rule out the possibility that atRA binds to and activates AHR, as opposed to other retinoids (Gambone et al. 2002; Soprano and Soprano 2003; Soprano et al. 2001).

However, some β3 knockout mice survive, develop a cleft palate and show behavioral changes.

In addition, it is well established that high doses of diazepam lead to craniofacial malformations in rodents [ 54- 57] and mice carrying targeted disruptions of the GABAergic pathway consistently develop a cleft palate, a rather common feature of Zellweger patients [ 58, 59].