Sentence examples for develop an efficacious from inspiring English sources

The urgency to rapidly develop an efficacious malaria vaccine has increased demand for efficacy studies that include CHMI and the need for comparability of study results among the different centres conducting CHMI.

The most significant challenge in schizophrenia therapeutics, thus, is to develop an efficacious treatment for cognitive impairments.

We have undoubtedly enhanced our knowledge, but the question now is how to use this information to manipulate immune responses against Plasmodium and to develop an efficacious malaria vaccine.

To develop an efficacious and safe nanotherapy against IBD, we designed and developed a superoxide dismutase/catalase mimetic nanomedicine comprising a hydrogen peroxide-eliminating nanomatrix and a free radical scavenger Tempol (Tpl).

Vaccination with live-attenuated Plasmodium sporozoites that arrest in the liver can completely protect against a malaria infection both in animal models and in humans; this has provided the conceptual basis for the most promising, but also challenging, approach to develop an efficacious malaria vaccine.

A fundamental goal of current strategies to develop an efficacious vaccine for AIDS is the elicitation of broadly reactive cytotoxic T lymphocyte (CTL) reactivities capable of destroying virally infected targets.

However, there has been considerable difficulty in developing an efficacious malaria vaccine, highlighting our incomplete understanding of immunity against this disease.

These results indicate that our plasmid DNA replicon vaccine can provide strong immunogenicity and should be a potential alternative strategy to conventional DNA vaccines in developing an efficacious vaccine against C. botulinum neurotoxin serotype A.

Unless the acceptability of microbicide is evaluated concurrently with efforts at developing an efficacious product, its eventual deployment is likely to be fraught with challenges that could undermine its effectiveness [ 21, 22].

The challenge of developing an efficacious H7N9 vaccine is further heightened by the presence of T-cell epitopes in the H7N9 HA that may cross-react with the human genome, which may alter or suppress immune response to the emerging H7N9 virus.

However, in the urgency to develop a medically efficacious microbicide, some of these concerns may not have been anticipated.