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However, most notably, we show here that with time, mutant skeletal muscles develop a wide spectrum of alterations including atrophy, fibrosis, lipid accumulation and a perturbed regeneration.
Hence, zebrafish is known to be susceptible to carcinogens affecting humans and develop a wide spectrum of cancers resembling human malignancies [ 8, 9].
Consistent with this hypothesis, SIRT4-deficient mice spontaneously develop a wide spectrum of tumors, and the absence of SIRT4 can accelerate cellular growth in MYC-induced B-cell lymphomas (Jeong et al., 2014; Jeong et al., 2013).
We speculate that this might be the major reason why p80HT mice develop a wide spectrum of B cell lymphomas including plasma cell tumors, as well as T cell lymphomas, which depend on the type and developmental stage of the lymphocytes that have acquired secondary genetic and/or epigenetic alterations.
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Bai et al. reported that a "double mutant mice develop a wider spectrum of tumors, including prostate cancer in the anterior and dorsolateral lobes, with nearly complete penetrance and at an accelerated rate" [333].
Both Tp53 Δ11/+ and Tp53 Δ11/Δ11 rats developed a wide spectrum of tumors, most commonly sarcomas.
iTools aims to provide an open, yet secure, infrastructure for resource archival, retrieval and traversal; communication between tool developers, clinicians, scientists and the general community; and to facilitate the interoperability of resources developed by a wide spectrum of investigators and employed in a variety of computational biology studies.
Try to develop a wide support network.
"You would definitely get a wide spectrum of people.
Dengue virus infections produce a wide spectrum of clinical illness.
Environmental agents produce a wide spectrum of renal dysfunction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com