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Of those, some will be hospitalized, and a few will develop a severe and potentially fatal syndrome involving kidney failure, anemia and bleeding.
Humans and other animals that become infected with hepatitis B virus may develop a severe and long-lasting form of liver disease known as hepatitis.
Its key role as a regulator of immune responses was well established in CTLA4-deficient mice that, upon exposure to environmental antigens after birth, develop a severe and lethal lymphoproliferative disease due to uncontrolled and persistent T-cell activation, proliferation and infiltration in peripheral tissues [34].
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Such individuals are at increased risk of developing a severe and potentially fatal illness known as eczema vaccinatum.
They generally develop a severe headache and a fever, and some may also have a red rash on their extremities.
Millions of dogs, cats and other non-conventional companion animals susceptible to L. infantum, living in European households, may develop a severe disease and contribute to the spread of leishmaniosis because of travelling or re-homing.
To develop a sepsis-screening tool, we first began a multidisciplinary sepsis-working group to develop a severe sepsis and septic shock alert for patients older than 14 years of age.
Remarkably, calves develop a severe thrombocytopenia and leukocytopenia within few hours after passive transfer of colostral antibodies to blood and die within several days from bleeding disorder and bone marrow depletion [ 1, 2].
In view of new developments in pharmacotherapy, it would be optimal to early identify those patients who are likely to develop a severe disease and enroll them for early aggressive treatment.
Transgenic ACTN4 mice develop a severe glomerular disease and FSGS [ 66, 86].
For example, mice lacking Bim [ 22] or Bid [ 23] develop a severe synovial inflammation and bone destruction in an arthritis model.
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