Sentence examples for develop a novel series from inspiring English sources

An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB1 agonists.

Recently resolved X-ray crystal structure of HIF-1α prolyl hydroxylase was used to design and develop a novel series of pyrazolopyridines as potent HIF-1α prolyl hydroxylase inhibitors.

To develop a novel series of CDK8/19 dual inhibitors, we employed structure-based drug design using docking models based on a library compound, 4,5-dihydroimidazolo[3′,4′:3,4]benzo[1,2-d]isothiazole 16 bound to CDK8.

We have developed a novel series of pyrrolidine derived BACE-1 inhibitors.

In order to increase HDAC inhibition and efficiency, we developed a novel series of saccharin hydroxamic acids as potent HDAC inhibitors.

As a proof-of-principle, we screened about 90,000 low-molecular-weight compounds from a publicly available small molecule database using the HTVS approach, and after two generations of optimization from a primary inhibitor lead, we developed a novel series of compounds with IC50 values in twenty micro-molar range against EBNA1.

We have developed a novel series of photosensitizers based on zinc phthalocyanine which are water-soluble and contain neutral (TDEPC), positive (PPC) and negative (TCPC) side-chains.

So we developed a novel series (SMAT and PfFSmat60) of substitution matrices which performed better in comparison to standard BLOSUM matrices and developed ApicoAlign, a sequence search and alignment tool for apicomplexan proteins.

The trench isolation technology is used to improve fabrication process of an actuator consisting of a large number of elastic electrodes connected in parallel and in series and to develop a novel low volume, large force (>1 mN) and nanometer resolution electrostatic actuator for low displacement applications.

In order to accomplish this, a need was identified to develop a novel TA method for application to a series of RALS tasks.

In this study, we describe testing of a series of protocols that enabled us to develop a novel optimized strategy for the enrichment and solubilization of ECM components.