To begin to identify the functional pathways within which CLN3 may function, we have utilized the opportunities provided by Drosophila to develop a gain-of-function genetic system.
We think that in some individuals, or in some perturbed situations, the fibrosis → sialidase → fibrosis feedback loop develops a gain greater than 1, significantly contributing to fibrosis.
This paper develops a gain scheduled controller to move a diesel engine through a driving profile represented as a set of 6 operating points in the state space of a 7th order nonlinear state model.
In the late 1980s, Dugan developed a gain limiting improvement to the automixing algorithm.
To test the possible therapeutic impact of further enhancing UPR responses after SCI, we developed a gain of function approach to artificially activate the UPR.
Typically, it takes anywhere from 12 to 19 years to develop a drug, gain regulatory approval, and bring a successful product to market.
After designing the base constant gain backstepping controller we develop an adaptive gain version of this backstepping control scheme.
In this paper, we develop a variable-gain (VG) control strategy that allows for a reference-dependent 'bandwidth' of the feedback controller.
The control is designed by extending the logic of SMA and integrating it with the LMI technique to develop a single-gain feedback controller that is capable of damping oscillations in large systems.
He was wrong, and therein lies a lesson for all hardworking scribblers: stick around long enough, develop a cult following, gain the approval of one or two literary dudes (in Whitman's case: Henry James, Ezra Pound, and F. O. Matthiessen), and you, too, can become respectable.
The team can use a short, anonymous survey of those involved in the alliance (for instance, the venture's top management team, its board members, and parent executives shaping decisions or spending more than 20% of their time on venture issues) to develop a fact base, gain quick agreement on sensitive issues, and build momentum for change.
