Suddenly a widower with no place to go, he develops a familial bond with Lupe, whose husband died in a car accident four years earlier, that is much deeper than his relationships with his two surviving biological children, Victor (Abel Becerra) and Alice Sandra Rioss).
An Arctic kindred that develops a familial form of AD has a mutation within Aβ (E22G) that leads to increased amounts of protofibrils [ 55].
This protein is generated by the cleavage of a precursor protein, and mutations in the gene that encodes amyloid precursor protein greatly increase the risk of developing a familial, early-onset form of Alzheimer's disease in middle age.
Curators develop a possessive, almost familial, relationship with their collections.
In contrast to cutaneous melanoma, there are no known risk factors for mucosal melanoma and there is no known premalignant phase, although it has recently been shown that cutaneous melanoma and mucosal melanoma may occur in the same patient and mucosal melanoma may develop in a familial setting.
As Beth begins to save enough money to move out, however, Will develops a grudging familial concern for both mother and child.
Alternatively, the carriers may suffer from defects that are very mild compared to the severe pathology in affected compound heterozygotes, and thus are not evident in a typical familial study, or will develop a phenotype later in life.
In a rare condition called familial fatal insomnia people lose their ability to sleep and develop a form of early-onset dementia.
"Over time, L.C. and Vilar developed a close, almost familial, relationship," it said.
