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Sepracor had been working with Eli Lilly to develop a compound dubbed (R -fluoxetine as a second-geneR -fluoxetinen of Prozas, the blockbuster antidepressant.
Structure based drug design was used to develop a compound library of novel 2,5,6- and 2,5,7-trisubstituted benzimidazoles.
The aim of this work is to develop a compound transdermal patch containing teriflunomide (TEF) and lornoxicam (LOX) to transport these drugs across the skin with the isochronous permeation rates for RA therapy and investigate intra-articular delivery of TEF and LOX following transdermal patches applied topically.
To develop a compound score, the individual covariates are summed; the association between such a compound covariate and outcome then is evaluated via regression analysis.
PGB was created in an attempt to develop a compound that would retain the biologic activity of gabapentin while improving its pharmacokinetic profile.
The other approach in which many researchers have adopted is to develop a compound that targets the downstream kinases of AMPK [i.e. a malonyl-CoA activator or CPT-1 (carnitine palmitoyltransferase-1) activator].
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They developed a compound to block the protease, and analyzed the way the compound worked.
"We were interested in developing a compound that would be a benefit to society".
Johnson & Johnson has already developed a compound to block the H-3 receptor, causing the thalamus to increase its production of histamines.
It was probably a bad day at the lab when scientists at the US drug group Pfizer's now defunct Sandwich research centre realised an angina treatment they were developing – a compound called sildenafil – simply didn't work.
Developing a compound of rubber, white lead, and sulfur and a heat treatment (or curing) process, Goodyear created a product at first called fireproof gum, afterward vulcanized rubber that exhibited impressive durability.
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