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Although the precise mechanism behind chloracne is not understood, sustained AhR hyperactivation and exaggerated hyperkeratinization of pilosebaceous units may be the cause of this devastating toxicity.
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What's In It: While its currently unknown what chemicals and compounds are in grapes that cause toxicity to dogs, the results of consumption can be pretty devastating.
While CRS can be devastating in course of treatment of liquid tumors, the risk for "on-target/on-tumor" toxicity for solid tumor seems to be lower.
Quietly devastating.
Devastating, even.
Just devastating.
Absolutely devastating!
Linda: Devastating.
responsible for devastating clinical manifestations.
"It's devastating, devastating news," Hixon said.
It is also devastating.
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