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Metastases of cancer to the bone represent the final, most devastating stage of malignancy and are the leading cause of death.
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This would avoid development of the devastating late stage of trachoma, called trichiasis, that makes surgery the sufferers' only salvation.
They report that sepsis-induced organ injury is attenuated upon delayed administration of an IKK inhibitor, suggesting that this inhibitor could be given to sepsis patients during the devastating late stages in disease progression.
"We are devastated to go out at this stage of the tournament.
As you continue to recover from Sunday night's devastating "Game of Thrones" Season 5 finale, you're probably still going through the many stages of grief.
Disablement affects over 40% of patients with advanced stage cancer, devastates their quality of life (QoL), and increases their healthcare costs.
Paul Zolenge, who owned the Stage Deli with Steve Auerbach, said the closing was "devastating, the end of an era, something I never thought would happen".
At this late stage of the bull market any slipups can be devastating.
Crawford appeared in good spirits Friday, saying that a five-goal game would have left him devastated when he played in juniors, but not at this stage of his career.
"I can understand why Steve Evans is so devastated to lose a key player at such an important stage of the season".
"It was devastating for all of us".
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