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Metastases of cancer to the bone represent the final, most devastating stage of malignancy and are the leading cause of death.
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This would avoid development of the devastating late stage of trachoma, called trichiasis, that makes surgery the sufferers' only salvation.
They report that sepsis-induced organ injury is attenuated upon delayed administration of an IKK inhibitor, suggesting that this inhibitor could be given to sepsis patients during the devastating late stages in disease progression.
Monica's eyes filled with tears from the audience, while Felipe was clearly devastated on stage.
Presence of weeds in the crop especially at early stages was devastating for wheat yields.
Djokovic and Nadal are in Shanghai, but none of Federer's competitors appear to be in devastating form at this late stage.
"It's been my dream since I was a young boy - to let it go at this stage would be devastating.
Even those who have come out against the GE-Comcast tie-up, like Bernstein Research analyst Craig Moffett, argue the implications of a deal falling through at this stage would be devastating to the Philadelphia-based cable company.
Blood-stage infections cause devastating symptoms and can persist for years.
This will be devastating in itself, but by that stage climate change may be difficult to stop and may trigger accelerated change.
To have fallen six points behind the Poles, even at this early stage, would have been devastating.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com