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This month alone has seen several devastating setbacks.
Someday, in the months ahead, there may be an Iraq where a smoothly run American occupation authority has dealt devastating setbacks to terrorism, brought security to most of the country, improved infrastructure and basic services, and elicited encouraging signs of democracy, economic renewal and cultural rebirth.
Reproductive health services have also suffered devastating setbacks.
Last year, one of my sons went through a series of devastating setbacks.
In January 1967, Nasa suffered one of its most devastating setbacks to that point.
The so-called "intervention" in 2007 was one of the most devastating setbacks suffered by Aboriginal people.
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Jerkens conceded it was a "devastating" setback to miss the Derby on Saturday.
Ed Miliband said the result was a "devastating" setback for David Cameron and he was determined to meet the challenge posed by UKIP.
Two years ago, the dream of having elected mayors running all of England's biggest cities suffered an abrupt and, some might say, devastating setback.
The slowly improving economy is returning some bargaining power to workers, while the high-profile strikes of 2013 have served as a shot in the arm after devastating state-level setbacks in places like Michigan and Wisconsin.
The setback was devastating news for many of Chavez's passionate supporters who have been praying for his recovery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com