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Acute spinal cord disorders are challenging, as they present a wide array of differential diagnosis and may lead to devastating sequelae.
Other ischemic and hemorrhagic lesions to the brain, such as subarachnoid hemorrhage or ischemia reperfusion after cardiac arrest, are also associated with high mortality and devastating sequelae [ 5, 6].
The targeted application of these novel techniques, with rigorous surveillance of vision (in a selected group of children with multiple risk factors for raised intracranial pressure), offers the only realistic measure to prevent these otherwise devastating sequelae.
Although intrinsic factors such as genetic mutations encountered in primary ciliary dyskinesia can alter cilia function with devastating sequelae, extrinsic factors such as pollutants and microbes can also directly and indirectly impact normal cilia function.
Our hypothesis remains that early nurse-led treatment at the point of referral to secondary care will be effective at managing constipation and will reduce the burden of children who fail routine secondary care and develop treatment resistant constipation and the devastating sequelae associated with soiling.
However, missing out on this finding would have led to a devastating sequelae.
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Anthrax infection is associated with devastating cardiovascular sequelae, suggesting unfavorable cardiovascular effects of toxins originated from Bacillus anthracis namely lethal and edema toxins.
These vary from minor complications to devastating neurological sequelae that can influence a patients' independence.
Acute hyperammonemia is a medical emergency requiring rapid recognition and treatment to prevent devastating neurologic sequelae.
The fact remains that diabetes and its sequelae are devastating and escalating public health problems that disproportionately affect the elderly, non-Hispanic blacks, and Mexican Americans.
The disease presents clinically with a broad range of manifestations including skeletal destruction, immune suppression and end-organ sequelae with devastating complications for patients and their quality of life.
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