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She had to drop out of high school to help her family during the devastating flu epidemic of 1918.
1918 "Spanish flu" The most devastating flu pandemic in recent history was caused by a strain of H1N1 influenza that killed 20 million to 50 million people worldwide.
Thirteen-year-old Cole has lost both his parents, and a good deal of his memory, to a devastating flu pandemic that has decimated communities and given rise to predictions of imminent rapture among the devout.
Pandemics, he said, can start out mild, and over the course of several months become a severe illness, as was the case during the devastating flu pandemic of 1918.
Aldous Huxley wrote Brave New World in 1931 in the shadow of the first world war, the Wall Street Crash and a devastating flu virus that had claimed millions of lives.
Senior medical officer Dr Nicola Steedman said every year she sees examples of how devastating flu can be.
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Five antibodies isolated by the team could fight all the seasonal H1N1 flu strains from the last decade, the devastating "Spanish flu" strain from 1918 which killed up to 50m people, plus a potentially deadly bird flu H5N1 strain.
The possibility that a pandemic as devastating as Spanish flu or a war with consequences as catastrophic as either the First or the Second World War could occur during the prediction period was included in the simulations based on data since 1900.
Chan is used to crises; as Hong Kong, China's Director of Health, she fought devastating outbreaks of bird flu and SARS before taking WHO's top job in 2006.
In Indonesia, however, bird flu devastated poultry in 2006 and infected 55 people, of whom 45 died.
This could cause a global flu pandemic as devastating as the one in 1918, which killed tens of millions.
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