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Further studies into metastatic mechanisms showed that SDF-1/CXCR-4 could modulate proliferation and progression of pancreatic cancer cells through CXCR-4-dependent activation of signal pathways, such as MAPK/ERK1/2, PI3K/Akt, FAK, Src, and STAT, which plays a core role in its devastating behavior [ 75– 75].
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"I have been aware of the problem, … and I understand just how pervasive, insidious, and devastating this behavior is".
In my own field of anthropology, I have been aware of the problem of sexual misconduct, and I understand just how pervasive, insidious, and devastating this behavior is.
In the final half hour of the play, Ben sees how really devastating his behavior has been to these people.
Bad behavior and devastating reversals build to a pitch of despair in the fifth and sixth episodes, in scenes that may shake you in a way nonlive television rarely does.
Though Ms. Wasserman Schultz said Mr. Wiener had been "incredibly apologetic" and "devastated" by his behavior, she added that his decision to take a leave of absence was not enough.
Mr. Weiner made the decision after long and emotional discussions with his political advisers and his wife, Huma Abedin, whom friends described as devastated by the behavior of her husband of 11 months, and worried about the couple's financial future.
Though Hitchcock's behavior devastated Hedren, she adds that their professional relationship was complicated.
Your firehose is full, and it leads to two behaviors that are devastating to Twitter: You visit less and you stop following new people.
No matter what type the Commitment Phobe may be, their behaviors are equally devastating to the women who love them.
Even if the concentrations of endocrine-disrupting compounds in the environment are not sufficient to cause structural effects and reverse sexual physiology, small adjustments in behaviors could still be devastating to reproductive success.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com