A detrimental feedback loop could be created where inflammation results in reduced bile absorption, therefore increased bile in the lumen, which in turn causes increased inflammation.
This interaction may suggest a detrimental feed-forward loop, where browning-induced lipolysis causes free fatty acid efflux, which in turn sustains the browning response during the hypermetabolic state.
Inflammation also drives tau hyperphosphorylation and aggregation [ 15, 51], so that a detrimental positive-feedback loop may ensue.
Increased p62 then fuels a detrimental positive feedback loop by which p62 itself leads to ROS production, enhanced induction of the protein folding machinery in the ER and a DNA damage response (108).
Although the Arg5-Ser6 scissile bond can be cleaved on SFTI without detrimental effect, the side loop does not have the features of a canonical loop and cleavage of the Gly1-Lys14 peptide bond may be irreversible.
Thus, we predict that if long feedback loops are detrimental because of their instability, then GRNs would be configured to minimize destabilization via the addition of new connections.
Results indicate that the control of engine-out exhaust gas temperature for faster catalyst light-off with catalyst not in the closed loop could be detrimental to the catalyst.
Also, AP amplification loop may cause detrimental activation no matter the initial trigger [54].
Similar to the current results, the introduction of thymine glycol or 8-oxo-A into a loop was not detrimental to the hybrid or basket structure based on CD and EMSA experiments.
SO2 was found to have a detrimental effect on the calcium looping cycle in both batch and continuous cyclic tests, although the presence of steam from natural gas-fired burners was found to have a positive effect on maintaining capture capacity of the sorbent.
