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This finding may be related to the exclusion criteria of the COMOESTAS Project, which required naïf MOH subjects (patients without a history of previous failure in detoxification therapy).
Recent prospective studies that included patients with triptan-induced MOH reported relapse rates after successful drug detoxification therapy of 38% in the first year and around 42% at 4 years [38, 41].
In summary, effective drug withdrawal may be obtained simply in an outpatient setting, at least in MOH patients presenting low medical needs and no previous experience of detoxification therapy.
Rossi et al. [24], in their study of 120 patients with migraine plus MOH, low medical needs and no previous detoxification therapy, found simple advice to be as effective as structured inpatient and outpatient detoxification programmes in achieving withdrawal from the overused medication (approximately 75% of patients in all groups).
Serum antibody titers to the main pathogens were slightly higher due to antibiotics and detoxification therapy.
Detoxification therapy, cognitive therapy, holistic therapy and a host of other types of treatment.
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There then appears to be a rapid increase in detoxification therapies prescribed in January-March 2007, reaching 277.
Time series analysis of secondary prescribing data pertaining to opiate maintenance therapies, opiate detoxification therapies and opiate related deaths for the time period 2003 to 2010.
Compensation was provided as it was acknowledged that opiate maintenance and detoxification therapies had significant potential to reduce harms associated with illicit drug withdrawal.
Recommendations for future research: Further observational studies and ultimately randomized controlled trials directed to the identification of the appropriate indications, timing of intervention, and cost effectiveness of supportive detoxification therapies.
These methods could, therefore, be used to verify GFD compliance to improve the diagnosis of cases refractory to the diet or with acute symptoms and for prolamine detoxification therapies in clinical research.
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