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This finding of Jensen et al. (2004) fits nicely with the fact that glutathione conjugation in particular is known to be a major detoxification route for PAs.
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The economic benefit of the potential detoxification routes is expected to increase if processes for upgrading Table olive processing wastewaters are designed.
Thereby, metabolism and detoxification routes will be discovered as recently demonstrated for DON and ZEN [ 24] to support advanced risk assessment.
Apparently, the 5-hydroxymethyl- 2-furoicc acid degradation "modules" have been recruited later in evolutionary history, constituting complete degradation pathways for furfural and HMF by complementing existing common aldehyde detoxification routes.
Such studies will improve the knowledge of the detoxification routes in non-target species and will help to design specific and safer carbamate and pyrethroid insecticides.
In mammalian systems, where numerous xenobiotics follow sulfation-dependet detoxification routes, sulfate transfer has been described as a high-affinity, low-capacity process [ 23].
In mammalian cells, the principal route for detoxification of this reactive metabolite is via the glutathione-dependent glyoxalase pathway forming d-lactate, involving lactoylglutathione lyase (GLO1; EC 4.4.1.5) and hydroxyacylglutathione hydrolase (GLO2; EC 3.2.1.6).
Although a number of pioneering works have been reported on treatment of arsenic containing wastewater by various techniques, only a few studies on a microbial route for detoxification of arsenic has been reported so far.
This data indicates that L. donovani mutants probably have a significantly reduced rate of metabolism of MG as compared to the wild-type parasites suggesting that the glyoxalase pathway is the dominant route for detoxification of MG in L. donovani.
The accumulation of ascorbate and H2O2 along the tonoplast and in vacuoles during these conditions indicates an important route for H2O2 detoxification under these conditions.
Determine if ZIP14 at the BL membrane of enterocytes provides an alternate route for systemic Mn detoxification.
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