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Sulfonation is considered a detoxification pathway for 3-OH-BaP.
Methylation is considered the detoxification pathway for inorganic arsenic (InAs), an established human carcinogen.
The presence of either a one-step or a two-step detoxification pathway for SAH follows a phylogenetic pattern.
Both Archaea and Eukarya use exclusively a one-step detoxification pathway for SAH, indicating that this may be the ancient type of metabolism.
We here identify a detoxification pathway for a prototypic chlorinated fatty aldehyde (generated via the MPO axis) that compromises BBB function in vitro and in vivo.
Here we describe a phloretin-mediated detoxification pathway for a chlorinated fatty aldehyde that has detrimental effects on BBB function in vitro and in vivo.
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To accomplish this, the major bioactivation and detoxification pathways for acetaminophen were investigated following retinol (75 mg/kg/day, 4 days), acetaminophen (400 mg/kg), and retinol + acetaminophen treatment.
This can be explained by saturation of detoxification pathways for formaldehyde at high concentrations.
Recently, the BSH-dependent detoxification of rifamycin in S. aureus Newman was shown to result in the mercapturic acid form of the antibiotic, an end compound that is analogous to the products of the mycothiol- and glutathione-dependent detoxification pathways for their respective organisms.
Three possible detoxification pathways for ATR exist in higher plants: (1) the dealkylation of cytochrome P450 in photosystem I, (2) the covalent modification of glutathione transferase (GSTs) in photosystem II, and (3) the hydrolysis of aromatic ring with nonenzymatic catalysis [ 1].
The OxyGene "Maps" tab provides several options for visualizing and comparing the detoxification pathway of any sequenced genome on maps built using the jgraph.jar library [ 50].
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