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The liver plays a major role in the metabolism and detoxification of compounds that reach the liver and hence the prime target organ for drugs and toxic substances [23].
The best known function of the CYP enzymes is the detoxification of compounds, such as anti-cancer drugs and xenobiotics in the liver.
Liver function tests are important indicators to reveal the functional status of liver since it is the vital organ involved in detoxification of compounds and in general metabolism.
Oxidoreductases catalyze the transfer of electrons between molecules and, in fungi, are involved in primary and secondary metabolism as well as the detoxification of compounds such as ROS, superoxide and hydrogen peroxide.
Oxidoreductases catalyze the transfer of electrons between molecules and in fungi are involved in primary and secondary metabolism (including cercosporin biosynthesis) as well as the detoxification of compounds such as reactive oxygen species, superoxide and hydrogen peroxide.
These enzymes are directly linked to the metabolism of xenobiotic compounds typically present in cacti, and previous studies revealed the activation of members of these gene families, including glutathione S-transferases (Gst), cytochrome P450, and UDT-glucuronosyltransferase (UGT), in the detoxification of compounds present in necrotic cactus tissue [ 10, 20].
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These genes are known to be involved in the detoxification of various compounds, particularly hydrophobic organic compounds [ 43].
GT performs the glycosylation of a wide variety of natural compounds, which is an important mechanism in detoxification of exogenous compounds [ 47].
The roles of the phase I and phase II enzymes are compound-dependent and therefore interdependent for effective detoxification of toxic compounds [ 23].
Toxicity studies by this lab demonstrated that selenium deficiency upregulates enzymes important to the detoxification of some compounds, while the same deficiency increases the toxicity of other compounds.
This suggests that RsHTMT in R. sativus may be involved in the detoxification of sulfur compounds produced by the degradation of glucosinolates to release them as volatile compounds.
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