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Consequently, GSTs have a critical role in the detoxification of cells and inactivation of drugs.
GSTs have an important function in the detoxification of cells in general, and the detoxification of tumor cells from such chemotherapeutic drugs in particular.
Therefore, PPARγ activity in the highly fat-producing ERBB2-positive cells may serve in the detoxification of cells from palmitate excess, by affecting its storage as triglycerides.
Restriction endonucleases, ABC-type transporters for the detoxification of cells, cation/multidrug efflux pumps, and enzymes involved in antibiotic resistance are all found within the COG V category.
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The members of the peroxiredoxin family have diverse functions associated with various biological processes including detoxification of oxidants, cell proliferation, cell differentiation and gene expression (Fujii and Ikeda, 2002; Jang et al, 2004).
Alternating glucose and galactose during the fed stage, allowed lactate detoxification of the cells through their own metabolism.
MRPs may therefore be crucial for the detoxification of tumor cells that have survived the initial PDT-induced ROS attack and can aid in restoring the intracellular redox balance.
The endocytic pathway by caveolin and clathrin ensured detoxification of the cell by expelling Cd2+ via the exosomes or its removal through lysosomal degradation, which oriented the pathway toward autophagy.
In E.coli K-12 LTTRs regulate nitrogen source utilization, amino acid biosynthesis and catabolism, oxidative stress response and detoxification of the cell [3], [4].
Metallothioneins, that are upregulated upon stress, are metal binding proteins playing a role in detoxification of the cell.
Consequently, we have hypothesised that the subcellular localisation of MDR ABC transporter proteins may have a role in the detoxification of the cell by efflux of compounds from within specific subcellular compartments (Maraldi et al, 1999), which may modulate induction of the intracellular cell death cascade.
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