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Here, we found that, in E. coli, loss of DksA profoundly impairs aerobic NO detoxification, approaching the detoxification capacity of Δhmp, which exhibits little-to-no NO detoxification within aerobic conditions.
This imbalance in detoxification capacity can be measured as increased production of PAH DNA adducts, decreased lipid peroxidation and compromised fetal health.
Changes in detoxification capacity through the interaction of autoclaving time and the amount of CaO were evaluated by an experiment with a non-detoxified castor seed meal and a 4 × 2 factorial design with four levels of CaO (10, 20, 30 and 40 g/kg) and two autoclaving times (15 and 30 min at 15 psi and 121 °C), with five replicates per treatment.
Heavy metals are toxic to plants if their accumulation levels exceed the detoxification capacity of the plant tissues (Zhang et al. [2007b]).
This ROS production exceeds the detoxification capacity of endogenous antioxidants and induces, e.g. necrosis, apoptosis, or cells with damaged DNA [34].
There is testing available today that tests detoxification capacity.
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Distinct from short-term responses, which were mostly regulated at the mRNA level, adapted cells seemed to sustain energy generation under repeated anoxia by partially sacrificing the NO detoxification capacities, and such adaptation was mainly regulated at the protein level.
- It is now possible to test detoxification capacities for different medications.
Finally, analyses relating to biological interactions are recommended, including determination of the bioavailability of nutrients and other bioactive components from pica substances, as well as their detoxification capacities and parasitological profiles.
The immature blood brain barrier of the fetus and young infant is more permeable to xenobiotics, and the fetus lacks drug-metabolizing detoxification capacities that are present postnatally (Rozman and Klaassen 1996).
More recently, binding, transport, and detoxification capacities of albumin have been found to be severely impaired in cirrhotic patients, particularly in those with acute-on-chronic liver failure precipitated by bacterial infections [ 35].
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