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Phytochelatins (PCs) are naturally occurring thiol-rich peptides containing gamma peptide bonds and are well known for their metal-binding and detoxification capabilities.
Phytochemicals have antioxidant, antimutagenic, anticarcinogenic, and carcinogen detoxification capabilities thereby considered as efficient chemopreventive agents.
First, the underdeveloped nervous systems of children have not yet acquired the detoxification capabilities to offset the effects of Pb.
In addition, HLSCs gain liver-specific metabolic activities such as detoxification capabilities, cleavage of the CYP substrate and urea production.
Elevated levels of antioxidant activity due to furfural challenge indicate increased oxidative stress, thus, accentuating innate detoxification capabilities of C. beijerinckii under the influence of furfural stress.
The fetal brain is expected to be particularly vulnerable because the blood brain barrier and detoxification capabilities are not yet fully developed.
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Mussel gills showed lower detoxification capability of QDs, while the digestive gland is the major tissue for storage and detoxification of both Cd forms.
Notice that enhanced detoxification capability would also reduce the dependency on angiogenesis for the removal of toxic compounds.
The extent to which xenobiotic chemicals cross the placental barrier may vary greatly depending on the type of exposures, timing in pregnancy, and maternal detoxification capability.
We also reported that individuals carriers of the SULT1A1 variant allele, who have limited detoxification capability of xeniobiotics through sulfonate conjugation, have an additional risk of gastric cancer if smokers.
Our data revealed a systematic redistribution of workload for multiple metabolic pathways leading to an enhanced detoxification capability and a reduction of electron transport chain (ETC) usage through a global downregulation of mitochondria-harbored pathways.
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