However, the percentage of total daily mercury excretion by the urine route can range from 10%to40%0%, depending on the amalgam filling exposure, and it is unclear how bio-detoxification affects this [ 61].
These compound detoxification is affected by feedstock nature, enzyme characteristics, and pretreatment harshness [26].
Also genes coding for proteins with domains involved in phase II of detoxification were affected by CPF (21) and DZN (14).
It is biologically plausible that the Val-9Ala and Ile58Thr polymorphisms play an important role in ROS detoxification, thus affecting the risk for developing cancer, particularly among individuals with a higher level of oxidative stress or who are deprived of other antioxidative protection, such as through a low level of antioxidant intake.
- Patients with poor gastrointestinal function often do poorly on medications, since this will affect detoxification.
A variety of antioxidant and detoxification systems were affected (Additional File 3 and Additional File 4f).
As proof of this principle, we tested the hypothesis that bacterial NO detoxification mechanisms can affect the abundance of host cell SNO, using a murine macrophage infection model.
Interestingly, in the present study, pathways including glutathione-mediated detoxification (Additional file 2: Figure S19) and removal of superoxide radicals (Additional file 2: Figure S20), which are both related to ROS scavenging and detoxification, were significantly affected post-GA3 treatment.
Although there are multiple potential detoxification mechanisms that affect the efficacy of chemotherapeutic drugs and confer drug resistance to targeted cells, GSH has a prominent role in resistance to chemotherapy [ 27].
These results suggest that nanosilver exposure affects both ARE and XRE detoxification pathways.
See related article in EMBO Mol Med (Biasco et al (2011) EMBO Mol Med 3: 89–101) ADA is involved in purine metabolism and detoxification, and its deficiency thus affects many organs with lymphoid cells being the least resistant.
