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Upregulation of GSTs in AA astrocytes may indicate active detoxification activity by GSH metabolizing enzymes, resulting lower levels of GSH as we demonstrated in vitro and perhaps in vivo.
Stomatal closure induced by hydrogen peroxide was reversed by exogenous application of ascorbate because of hydrogen peroxide detoxification activity of ascorbate (Zhang et al. 2001).
Subsequent modification of PEMs with type I collagen and the proteoglycan decorin did not alter substrata compliance, but enhanced the retention of spheroids on surfaces and stabilized hepatic functions (albumin and urea secretion, CYP450 detoxification activity).
Moreover, we evaluated the menadione detoxification activity (DT-diaphorase) and the antioxidant defences of guinea pig and rat hearts, namely their GSH/GSSG content, Cu/Zn- and Mn-dependent superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (Gpx) activities.
The increased energy production in liver suggested by these changes can be related to the increased detoxification activity known to occcur in liver after PAH exposure, and can be also related directly or indirectly to the changes observed in the levels of plasma steroids.
Cytochrome-P450 dependent EROD or BROD detoxification activity was measured using ethoxyresorufin or benzyloxyresorufin as substrate.
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The age-dependent expression in C flies was also characterized in activation of genes involved in cytochrome P450, which suggests elevation of detoxification activities.
In ancient books, mung beans were well known for their detoxification activities.
It is well known for its detoxification activities and is used to refresh mentality, alleviate heat stroke, and reduce swelling in the summer.
A number of genes for membrane transporter systems with detoxification activities were down-regulated in young cells only.
Equipping crops with DON detoxification activities may reduce the mycotoxin concentration in grain and also increase plant resistance against infection.
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