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It will be of great interest to further enhance our understanding of how this mechanism works and affects other dimerizing TF families, like the bHLH and nuclear receptors, determining whether this pattern is global or restricted to the bZIPs.
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Objectives: A pilot study was designed to analyze lymphoid cell infiltration in Epstein-Barr virus positive (EBV+) nasopharyngeal carcinomas (NPCs) and to determine whether this pattern of infiltration is consistent with non-EBV+ head and neck carcinomas or with solid EBV+ tumors in other locations.
We next sought to determine whether this pattern would also be observed in early visual areas.
To determine whether this pattern of drug-resistance mutations was common to other XDR strains from KZN, we sequenced eight additional strains fitting the XDR profile, including clinical isolates obtained from other sites in the KZN region: TF274, R257, R503, R262, R299, TF275, R376, and TF490 (the three 'TF' strains were obtained from Tugela Ferry, approximately 60 miles north of Durban).
Longer time to evaluate will allow us to determine whether this pattern holds beyond 2 years.
Next, we determined whether this pattern would be reflected in tumor growth of PC3 xenografts.
A follow-up survey would help determine whether this pattern occurred in this outbreak, or whether there continues to be a significant number of unreported cases.
Further work is now required to determine whether this pattern of activation represents a general mechanism for signalling by plexin receptors, and for the inhibition of Rap.
We have begun investigating levels of introgression at field sites where D. carinulata has failed to establish to determine whether this pattern holds true.
We wanted determine whether this pattern of adherence applies to refill adherence for statins, using a method validated in the Swedish setting.
Ongoing epidemiologic surveillance will be necessary to determine whether this pattern of HFMD and enterovirus activity recurs in a regular annual cycle.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com