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In the hematopoietic system, Gfi1 plays a key role in restricting HSC proliferation and preserving their functional integrity [13], [14], in controlling T cell differentiation [15], [16], and in determining the differentiation of neutrophils [17], [18] as well as dendritic cells [19].
Alizarin red staining is considered to be an important tool for determining the differentiation of MC3T3 osteoblastic cells (osteogenesis).
Sim, its homologue in Drosophila, is a key factor in determining the differentiation of central nervous system (CNS) midline cells [ 82].
A combined tracer evaluation of Ga-68 DOTATATE (GaTate) and F-18 FDG (FDG) positron emission tomography (PET-CT) and the ki-67 marker have potential advantages over a single marker in determining the differentiation of NETs.
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In the model system Drosophila melanogaster, doublesex (dsx) is the double-switch gene at the bottom of the somatic sex determination cascade that determines the differentiation of sexually dimorphic traits.
We also determined the differentiation of newborn cells into neurons and glia by performing double-immunostaining using neuronal and astrocytic markers (Fig. S1).
Only Bcl-6 could determine the differentiation of germinal center Tfh cells [ 27, 42, 43].
The eminent work of Brown & Sax [ 57] shows that mechanoperception of the pressure exerted by surrounding cells determines the differentiation of phloem and xylem.
To determine the differentiation of MDSCs to LEC precursors, the lymphangiogenic characteristics of MDSCs cocultured with 50% supernatant of HLECs were compared with native MDSCs and HLECs.
To determine the differentiation of p75NTR+ cells, single viable floating p75NTR+ cells were collected and resuspended to 1 × 103 cells/mL in keratinocyte-SFM medium containing 10% fetal bovine serum.
To determine if there exist common pathways that determine the differentiation of osteoblast, chondroblast and chordoblast (notochord epithelium cells), and thus a possible evolutionary link in tissue morphogenesis, key genes directing mesenchyme stem cells toward osteogenic and chondrogenic lineages were searched, and the expressed genes are listed in Figure 6.
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