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Perié, L. et al. Determining lineage pathways from cellular barcoding experiments.
Final decisions on lineage choice may thus be determined by the combination of TCR affinity and strength of the TCR signals with absolute levels of signaling determining lineage commitment choices.
Last, defining cell intrinsic factors which may be important in determining lineage commitment and cell fate in the mammary epithelium.
The high mortality following PDL plus alloxan hampered the genetic lineage tracing, which is considered to be the gold standard for determining lineage relationships.
Because the majority of hearts (32 of 38 embryos) contained three or fewer uniquely colored clusters, determining lineage relationships between and among clusters was straightforward.
The PCR results confirmed the lineage specificity for all genes analyzed, suggesting that the CGH approach was accurate for calling gene presence or absence and determining lineage specificity.
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Acetylation of histones and methylation of histones and DNA cytosine residues are part of the complex epigenetic regulatory process determining lineage-specific gene expression by altering the local structure of chromatin.
Mitochondrial genes demonstrated utility for determining lineages of geographically separated OTUs [ 49, 55] and all five OTUs have discrete 16S, 12S and cytb haplotypes.
Hoskin said the tests cannot even reliably determine lineage among North or South American tribal groups.
Wei J, Wunderlich M, Fox C, Alvarez S, Cigudosa JC, Wilhelm JS, et al. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.
Through this process of dividing and trapping, researchers were able to track where single cells traveled after division and to determine lineage relationships for multiple generations.
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