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They absolutely have their place in determining efficacy and causality.
Complicating the process of determining efficacy is how the data are gathered: patients in these trials typically assess their own degree of symptom relief, which many allergists concede makes the data somewhat subjective.
For small cohort sizes determining efficacy is challenging and dependent on selection and quality of outcome criteria.
Determining efficacy in complementary medicine research requires valid placebo/sham control groups that are credible to patients and ensure successful blinding.
The role of polymer physicochemical properties in determining efficacy of transgene expression was investigated using Quantitative Structure Activity Relationship QSARR) cheminformatics models based on Support Vector Regression (SVR) and 'building block' polymer structures.
Evidence was drawn from randomized controlled trials, which represent the gold standard for determining efficacy and effectiveness.
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To determine efficacy, one must look at the evidence.
Validated instruments were rarely used to determine efficacy, and most outcome measures were subjective.
To determine efficacy of Pillar palate implants for mild to moderate obstructive sleep apnea (OSA) syndrome.
To determine efficacy and safety of asoprisnil in patients with leiomyomata.
PURPOSE: To determine efficacy of anti-human interferon-γ F ab′ 2 (Fabs) in treating corneal transplant rejection after penetrating keratoplasty.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com