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Perturbation at any level of these structures can have a significant role in determining domain accessibility which can either improve or inhibit activity in that region.
Our assumption that modular domains rearrange during protein evolution played a role in determining domain boundaries.
This indicated the RRH 555-557) is the determining domain in GEP for heparin binding.
Because of noise in the data, a naive threshold-based approach for determining domain position was highly inaccurate.
The 9aaTAD was not used in determining domain architecture as it does not contribute to any unique domain combination.
This computational approach for determining domain boundaries splits multi-domain proteins into single domains and non-compact strands and loops are removed as well, thus even single-domain proteins may be shortened by this method.
Similar(51)
Problems related to determining domains with non-compact automorphism group are notoriously difficult (see, e.g., [45]), and the above result relies on our classification in an essential way.
In 1998, two organizations were established: the Domain Resolution Body, to determine domain disputes, and Norpol, a political advisory board.
In order to determine domain level hits, the SCOP IDs from the models that encompassed the hits for each superfamily were used to map to Pfam domains through the PDBMAP mapping provided by Pfam.
To determine domain boundaries, we included functional and structural information.
More powerful tools are needed to obtain an accurate alignment across the full domain model and to determine domain boundaries.
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