In cardiac surgery with extracorporeal circulation (ECC), several factors (for example, hemodilutional anemia, myocardial stunning resulting in a low cardiac output (CO)) can determine an imbalance between O2 demand and DO2 and may affect the outcome.
Specifically, while in EE, the accumulation of sulfide causes the inhibition of cytochrome c oxidase (COX), the systemic accumulation of thymidine and deoxyuridine in MNGIE determines an imbalance of the dNTP pool that interferes with mitochondrial DNA (mtDNA) replication and leads to depletion, multiple deletions and point mutations, and thus mitochondrial dysfunction.
This study aims to determine whether an imbalance between the loss of dopaminergic and serotonergic neurons precedes the development of dyskinesias in PD.
In the present study, we investigated the role of GalR1 in the pathogenesis of KA-induced excitotoxic neurodegeneration by using GalR1-deficient mice and WT mice to determine whether an imbalance in the galanin receptor system altered neuronal degeneration.
Of interest, we could determine that an imbalance in XIAP/XAF1 mRNA expression levels correlated to overall patient survival, and that high XIAP immunoreactivity was a poor prognostic factor.
Local angiogenesis is determined by an imbalance in the over-expression of pro-angiogenic factors, as compared to inhibitors of angiogenesis.
To determine how an imbalance of elastase and elafin in tumor cells could increase their tumorigenic potential, we overexpressed elafin or knocked down elastase in tumor cells.
13 Moreover, osteoblast function declines with aging, determining the imbalance between bone resorption and bone formation.
Consistent differences in constraints on trait evolution in insects and plants may also play roles in determining the imbalance of armaments.
The proposed balancing system employs local and cluster monitoring mechanisms in order to observe the distributed load changes and identify imbalances, repartitioning policies to determine a distribution of load and minimize imbalances.
The load balancer uses an octree-based method to calculate the amount of imbalance and determine a new partitioning for the hybrid mesh.
