Sentence examples for determining accessibility from inspiring English sources

Our data show cell-type-specific patterns of DNA and histone modifications provide a modulatory layer by determining accessibility of genes to regulation by TGF-β/SMAD3.

The challenge is that data backup and recovery is a costly process [ 144 ] and requires acute focus on data selecting, mapping, testing and determining accessibility roles in case of recovery process.

Genetically determined accessibility was enriched at distal enhancers, but random monoallelically accessible (RAMA) elements were enriched at promoters and may act as gatekeepers of monoallelic mRNA expression.

(b) Length of the stalk region determines accessibility of a displayed protein as a function of molecular weight.

Selection of adequate sub-molecular target epitopes determines accessibility for anchoring of drug conjugates and bulkier drug carriers, as well as proper signaling for uptake within the cell.

Therefore, the different nucleosome distributions in our three cell types could not explain the FAIRE patterns, confounding views that nucleosome patterns per se determine accessibility.

These parameters were used to determine accessibility of enzymes depending upon their action pattern and directly affect the hydrolysis process.

One-third of Kenyan policy makers and program implementers and one-half of the Rwandan counterparts pointed out that the cost of an LAI would largely determine accessibility.

The chromatin structure surrounding the transcription start site, determined by the distance between individual nucleosomes comprised of DNA wrapped around histone octamers, is determined by both DNA methylation and histone modifications and determines accessibility of the DNA for transcription factors.

The chromatin structure can be modified through covalent modification to either the DNA or the histones, which in turn determines accessibility and recruitment of transcription factors and RNA polymerase II to the DNA.

In the present study, we focused on TM10 of OATP1B1 and performed cysteine scanning mutagenesis to determine accessibility and potential involvement of individual amino acid positions in the substrate binding site/translocation pathway.