The two overlapped fragments would then be subjected to canonical splicing motifs search, i.e. 'GT-AG', 'GC-AG' and 'andAC', to determine a stop point for spliced alignment.
Fig. 3 Different types of pauses determining a full stops and b commas in aspect of types of filled pauses signalizing punctuation [23] Fig. 4 Different types of pauses determining full stops and commas [23] Fig. 5 Proportions of filled pauses and breath pauses occurrences correlated with full stops or commas [23].
Furthermore, a novel, never reported, point mutation, was found, which determined a premature stop codon in the aminoacidic sequence that resulted in a truncated protein in the tyrosine kinase domain, thus impairing the inhibitory effect of specific therapy.
We determine a growth stop criterion either by specifying a maximum number of nodes, or by specifying a fixed number of iterations of the algorithm.
The theory of optimal stopping developed in pricing American options can be further applied to determine an optimal stopping point so as to maximize return from financial investment for economic agents.
An additional, non-cancer-associated frameshift mutation (1955 del 1 bp), which determines an early stop codon at position 660, was used to evaluate the impact of a clear loss-of-function mutation.
Recently, it has been demonstrated that also the distance of the stop codon to the poly(A) tail can determine whether a stop codon is recognized as normal or premature [4], [5], [6].
The analysis enables the system to determine an automatic stopping criterion to reduce the computational complexity of the iterative process.
For the efficient production of [11C]CO2, the desirable target shape and internal volume were determined by a Stopping and Range of Ions in Matter (SRIM) simulation program, and the target grid was modified to resist the cavity pressure during beam irradiation.
The key research question with operating such a bus circulator system is how to optimally determine a bus route and stopping sequence for each circulating tour by using the real-time demand information.
