Sentence examples for determining a rationale from inspiring English sources

Computational models will need to be developed to determine how polygenes and environmental factors interact to perturb cellular regulatory networks, affecting cellular phenotypes and determining a rationale for targeted prevention of disease (Schadt et al. 2009).

Using combined experimental and model results, the effects of temperature and coating thickness were determined and a rationale was developed for coating lifetime prediction.

However, the paucity of data from the heterosexual male and non-HIV-positive or non-high risk female populations (largest sections of the general population who make up a substantial number of anal cancer patients) has been a problem in the clinical management of these patients, particularly in determining the rationale and feasibility of instituting a screening program.

The rationale of this strategy resides in the fact that the lipid biosynthesis is an essential metabolism for cell growth, thus its inhibition by cerulenin determines a marked reduction in the growth of the colonies on the culture plates.

Our aim was to define: i) the expression pattern of PDGF-B and VEGF-A in tumor cells and activation of PDGFR-β tyrosine kinases in stromal cells of human gastric adenocarcinoma; and ii) the relationship between VEGF-A and PDGF-B expression and MVD, to determine whether there is a rationale for a new therapeutic strategy.

Our aim was to define: i) the expression pattern of VEGF-A and PDGF-B in tumor cells and the activation of PDGF receptor (PDGFR -β tyrosine kinase in stromal cells of human gastric adenocarcinomas; and ii) the relationshiPDGFR -βn VEGF-A and PDGF-B expression and microvessel densityrosine, to determine if there is a rationale for a new therapeutic strategy.

These diagnostic tools may provide a rationale for determining the therapeutic regimen in the individualized treatment of breast cancer.

To determine the rationale for these differences in expression patterns, we analysed the expression level of all the co-amplified genes in five xenografted and one fresh human gliomas containing dmins, the sequence of which has been previously analysed in detail [14], [15].

However, it is not possible to definitively determine the rationale for stopping antibacterial therapy.

Additionally, there may have been a clinical reason why some participants had a PIM/PPO; however, as no clinical notes were available, it is not possible to determine clinicians' rationale for such prescribing decisions.

The hydroxyl radical scavenging ability of melatonin was used as a rationale to determine its radioprotective efficiency.