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Whereas a significant downregulation of Mcl-1 and Bcl-xL survival proteins was also observed in U266 cells following 4EGI-1 thistment, this cell line did not undergo apoptosis, which indicates that the reduction in expression of these anti-apoptotic proteins was not sufficient for determining a commitment to cell death.
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An organization may have a policy that determines a commitment to use a particular methodology.
"My sense... is that he is a person who sizes up opportunities and situations very quickly [and] when he determines to make a commitment to do something, he does it and doesn't look back," Kirby said.
The size of the study was determined based upon a commitment to the US Food and Drug Administration FDAA) to provide safety and efficacy data for adalimumab when used in 2 to <4 year old patients with JIA, and, in accordance with the FDA, the proposed sample size for this study was approximately 30 patients.
Phillip G. Cottel argued that in order to uphold strong ethics, an accountant "must have a strong sense of values, the ability to reflect on a situation to determine the ethical implications, and a commitment to the well-being of others".
With the right strategies and a determined commitment to a united Ireland can happen.
A determined commitment to attract and prepare highly capable and motivated individuals should take the form of a specialized child welfare track as part of university graduate psychology programs.
This functional trauma system requires a determined commitment to education, planning and coordination, financial resources and well staffed hospital emergency services.
13, 14 It is clear that a complicated interplay among proapoptotic and antiapoptotic proteins is responsible for determining commitment to cell death from many perturbations.
This century it started to resemble a truly professional organisation, with its own chief executive and staff and, since January last year, a more determined commitment to projecting itself to the public.
Patient safety culture can refer to "the product of individual and group values, attitudes, competencies and patterns of behavior that determine the commitment to, and the style and proficiency of, an organization's health and safety programs" [ 4].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com