Sentence examples for determines the accessibility of from inspiring English sources
The field of epigenomics involves the study of chromatin, the three dimensional complex of DNA, protein and non-coding RNAs that determines the accessibility of DNA by the transcriptional machinery.
Chromatin architecture plays a critical role in the control of eukaryotic gene transcription in vivo because it determines the accessibility of genomic regulatory sequences to the transcriptional machinery.
This is because the viral conformational structure determines the accessibility of epitopes which then determines the neutralization of the virus.
Chromatin structure greatly affects transcription in eukaryotes as it determines the accessibility of different regions of DNA to the incoming binding factors.
Since DNA methylation is tightly linked to the local chromatin configuration which in turn determines the accessibility of the DNA strand, this may indicate a coordinated regulatory relationship between these transcription factors, but clearly, further investigation is needed here.
It is becoming evident that the intracellular trafficking of APP determines the accessibility of APP to the cleaving secretases, i.e., APP is processed differently in the endosomes than at the cell surface.
The later relies on a hinge-like movement of the N- and C-lobes to adopt an open or closed conformation, consequently, determining the accessibility of the active site and substrate specificity.
While the expression levels of cytoplasmic 208-CTF and hTDP-43NLSm proteins are comparable, the high insolubility of 208-CTF protein42 when compared with hTDP-43NLSm26 malsolso determine the accessibility of the pathological TDP-43 seeds, thereby affecting the efficiency of seeding and propagation of TDP-43 pathology in CamKIIa-208 mice.
We employed fluorescence quenching to differentiate between the structures of Ca2+-bound and apo NCaBD by determining the accessibility of Trp residues to acrylamide.
AADT line information obtained from the Maryland State Highway Administration is used to determine the accessibility of potential park-and-ride station locations: the roadways near the candidate location should carry significant traffic volumes, as shown in Fig. 6.
