Much of this uncertainty stems from an insufficient understanding of the key drivers determining decision made by the healthcare industry, academic clinical trial units (CTUs) and clinical research organisations (CROs) in selecting European trial sites.
A mixed method approach was employed, whereby a focus group was initially conducted with 43 Agile developers and managers to determine decisions made at different points of the iteration cycle.
These categories are composed of different dimensions that determined decisions made regarding work and caring, the benefits and challenges associated with either work or caring, or the combination of both, and they either facilitated or impeded work or care (see Figure 1).
The stakeholder salience model (Mitchell et al., 1997) describes how a manager's consideration of shifting saliences determines decision-making based on paying attention to definitive stakeholders.
While the authors correctly point out that when considering treatment options at initial diagnosis it should be the patient's absolute risk of a further ipsilateral tumour that determines decision-making, the authors' own findings of increased survival in the more recent patients managed aggressively with chemotherapy mean that more women will be surviving to develop ipsilateral disease.
In principle, the projects cover the whole range of geographical levels which mark the boundaries of their impacts and determine the decision making bodies concerned: from international to national and local.
Prior to examining options for change, the panel must determine a set of decision making criteria on which the activity will be based (stage 4 of Table 1).
We just look on previous year's target, what we planned and what did we achieve; then we predict what is required" (NGT, 2010) Theoretically, prior to examining options for funding, the planning teams must determine a set of decision making criteria on which the priority setting will be based.
Social interactions provide the basis for social networks, which determine choices and decision making.
Surgical and pre-operative treatment choices are best determined by multidisciplinary decision making based on detailed assessment of the primary tumour, as well as staging for the presence or absence of metastatic disease.
