As already reported, growth factor stimulation determines a down-regulation of HER3 caused by the ligand-stimulated degradation of the receptor, that does not involve HER2 despite the dimerization of the two receptors [26].
Over-expression of CD99 determines a down-regulation of mesenchymal markers, such as fibronectin, and the transcription factor snail1.
In mice, PQ exposure determines an up-regulation of α synuclein, accelerating the formation of aggregates in the substantia nigra (Manning-Bog et al. 2002).
In some cases, different TCs with identical predicted annotation showed a contrasting accumulation pattern between developing stages or between genotypes; this implies that similar, although not identical, proteins and enzymes may undergo different expression patterns, determining a fine regulation of metabolic pathways and the accumulation of alternative metabolites.
Despite extensive study of these signaling cascades, until recently RTK internalization was believed to determine a down-regulation of RTK activity, ultimately leading to receptor degradation.
The use of corticosteroids for the treatment of retinal edema is linked to their capacity to inhibit the initial arachidonic acid cascade, to determine a down-regulation of the cytokines and to attenuate the tearing of the hemato-retinal barrier [ 7, 15, 33].
We show an increase in proliferation in both OE and VNE, determining an up-regulation of neurosensorial cell turnover.
Hence, different levels of C16:1 n-7 may determine a differential systemic regulation that may explain the phenotypic variations observed between groups.
The primary intended use of block decoys is in vitro gene regulation studies in which bespoke chimeras can be rapidly constructed and utilized to determine a promoter's functional regulation.
We examined the expression patterns during our time course to determine a set of principal regulation profiles for genes that are up-regulated during the first 60 min of cilia regeneration in Chlamydomonas.
