To address these important questions, first we determined whether Wit could interfere with the ability of growth factors such as EGF to stimulate the tyrosine phosphorylation of STAT3 and STAT5.
Having determined that Wit prevents the activation of STAT3 by blocking its ability to associate with the EGF receptor in MDA-MB-468 cells, we next sought to determine whether the inhibition of STAT3 signalling with Wit leads to inhibition of malignant transformation.
His combative, determined manner, combining candor, wit, and confidence, "carried the exhilaration of a spring morning walk along the cliffs," in the words of one observer.
To this end, we determined the effects of Wit on apoptosis, anchorage-dependent and -independent growth, invasion, and tumour growth in vivo.
We next determined the effect of Wit on breast tumour growth in vivo in a transgenic mouse model in which mammary tumour development is driven by ErbB2, a RTK known to activate both STAT3 and STAT5.
On the anniversary of a fateful white-water rafting trip, a trio of independently spirited women reconvene in the Appalachian Mountains, part of a six-strong girl group determined to pit their wits against the area's labyrinthine caves.
Even without Semi Radradra, Beau Champion, Junior Paulo and Tepai Moeroa the Eels — inspired by their determined defence and the barrelling wit of Chris Sandow — fought back from a deficit to push clear and hold off the premiers (themselves down a few regulars).
It would be frightened out of its wits, but still determined to stand with and comfort its lover.
Mr. Sayles dramatizes those contradictions with wit and concision, and with determined fair-mindedness as well as outrage.
The antibiotic loading amount was determined according to the recommendations made by Witsø et al. [ 12].
