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The idea is that each contract will be a locally determined variant on a public-private partnership.
As described below, this empirically determined variant calling approach improved the overall sensitivity to detect variants compared to the standard HCDiff variant detection algorithm, particularly at low coverage targets (Fig. 3A).
The novelty of this work is to validate the right combination of aligners and variant callers against a comprehensive and experimentally determined variant dataset: NIST-GiaB.
A possible confounding factor in the present study is that, within a study group, the frequency of individuals carrying a determined variant allele may change with age in the event that the presence of such allele would be related to severe diseases.
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The allophones of a phoneme, then, are its contextually determined variants and they are in complementary distribution.
Granted that [p] and [ph] are variants of the same phoneme /p/, it can be said that they are contextually, or positionally, determined variants of it.
The microarrays were scanned (Innopsys S.A., Carbonne, France) and we determined variants using a developed software that converts the intensity of the spots into the genotype of each variant.
The chromatograms of all the computationally determined variants were confirmed manually.
In this study, we determined variants of HSP70 genes in IPF patients and healthy controls from Mexican ancestry.
SWAN also uses soft-clip/split read remapping to supplement the likelihood analysis and determine variant boundaries.
Likelihood ratios showed that dialect was a significant factor for determining variant distribution in both contexts [rounded: χ2(3) = 10.82, p = .01; unrounded: χ2(3) = 12.28, p < .01].01]
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CEO of Professional Science Editing for Scientists @ prosciediting.com