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However, due to imperfections in present classical force field methods, the precise active site water arrangement could not be determined until now.
The presence of an IS 6110 element in the promoter region of phoP in BCG-Russia, -Japan, and -Moreau has been described previously, but its insertion site and orientation were not determined until now [ 49].
While D. reticulatus is known to be a vector of Babesia canis [ 24], Rickettsia slovaca [ 25] and Coxiella burnetii [ 26, 27], the vector competency of this tick for A. marginale has not been determined until now.
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What researchers have been unable to determine — until now — is what those differences mean for business productivity and profits.
The anti-apoptotic effect of AM on glioblastoma cells was only determined in vivo until now.
An in-store display, for example, can hold a customer's attention for several minutes, Genauer said, but it's difficult to determine their reaction — until now.
He is also going to have to prove a lot more nimble and determined than he has until now to tackle the crisis.
Until now, determining the sex of dinosaurs has been impossible without pelvic bones.
Anti-HMGCR IgG subclass distribution, which had remained unknown until now, was determined.
The isomeric configuration of the alkenes was not determined in this study; however, until now, Z-alkenes were primarily found in plant cuticles [ 21].
The Supreme Court has been stymied until now in determining how much partisan gerrymandering is too much.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com