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The RCGs determined to be functionally characterized by the majority rule were then used for two purposes: to generate high-confidence functional predictions for the genes included in the functionally characterized RCGs to identify promising new candidate disease genes for OMIM [9] phenotypes of unknown molecular basis, but for which one or more genetic loci have been identified.
Mononuclear phagocytes (MNPs) are also determined to be functionally changed in patients with HNSCC [ 8].
As shown in Table 1, among the 17 variants determined to be functionally retained variants, 11 were tolerant, and six were sorted as affected by SIFT.
Among the 13 variants determined to be functionally defective, two were sorted as tolerant and 11 were sorted as affected by SIFT.
The regions determined to be functionally active (i.e., rejecting the null hypothesis H0) according to the t-statistics map of the original full-sampled data were chosen as the ROI for further analysis.
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Some of the genes that were determined to be differentially expressed are not functionally annotated (N = 16, 31%).
Given the significant correlation between the increases in fim3B and US pertussis case notifications, the effect of the fim3 mutation needs to be functionally and clinically determined.
To determine whether Chokα was functionally relevant to choline metabolism, Jurkat cells were treated with CK37, a specific inhibitor of Chokα.
To determine whether sst may be functionally important in proliferation, dose response curves were constructed with the somatostatin analogues Octreotide and SOM230 (a gift from Novartis Ltd ,Basle, Switzerland).
To determine whether AS is functionally critical for myotube hypertrophy, the influence of AS (10 ng/mL) on myotube thickness was examined.
Four approaches have been predominately used to determine how neurons are functionally connected and how information is distributed in the AI microcircuit.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com